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Project Three: MR Imaging of Failed Regeneration and Cardiopulmonary Function

PI:

Co-PI:

Glenn Walter, PhD, University of Florida

Krista Vandenborne, PT, PhD, University of Florida

Aim 1: Prospectively determine the association between LTBP4 polymorphisms and cardiac disease progression.

Aim 2: Examine the impact of LTBP4 IAAM haplotype on MR measures of respiratory muscles and loss of pulmonary function.

Aim 3: Retrospective study of the association between SPP1 and LTBP4 gene polymorphisms and disease progression in the lower extremity muscles in a large DMD cohort.