PI: Elisabeth Barton, PhD, University of Florida
Critical to the evaluation of potential therapeutics (pharmacological, gene, or cell therapies) are sensitive and repeatable physiological assessments of muscle function applied to mouse models of dystrophy. This research core performs ex vivo, in situ, and whole animal assessments of muscle integrity and function. This core not only supports the needs of the projects within the center, but serves as a national resource for performing functional evaluation of potential therapies for the muscular dystrophies. Details on the Core services can be found on the Myology Institute Website at http://myology.institute.ufl.edu/shared-resource-core/.
Aim 1: Perform in vitro and in situ tests of muscle function and injury.
Aim 2: Perform assessments of muscle function and integrity in living mice.
Aim 3: Maintain in-house colonies of mouse models of DMD and LGMD.