Eccentric Contraction

Pattern of force graph and contractile damage in  a diaphragm

Figure 1. Left panel, The pattern of force generate by a single eccentric contraction. Each contraction, separated by a period of 5 minutes, consists of an 80 Hz -700 msec pulse delivered via two parallel platinum plate electrodes, where a stretch of 10% Lo is imposed on the muscle in the last 200 msec of the contraction. Right panel, Procion orange dye uptake in a diaphragm.

Related Literature

Barton, E.R., B.J. Wang, B.K. Brisson, and H.L. Sweeney. (2010) The diaphragm displays early and progressive functional deficits in dysferlin deficient mice. Muscle Nerve. 42(1):22-9. PMID: 20544921

Barton, E.R. (2010) Restoration of gamma-sarcoglycan localization and mechanical signal transduction are independent in murine skeletal muscle. J. Biol Chem. 285(22): 17263-70. PMC2878052

Barton, E.R., J.D. Molkentin, E.M. McNally. Targeting latent TGFβ release in muscular dystrophy. Sci Transl Med. 2014 Oct 22;6(259):259ra144. PMID: 25338755

Ceco E, S. Bogdanovich, B. Gardner, T. Miller, A.DeJesus, J.U. Earley, M. Hadhazy, L.R. Smith, E.R.Barton, J.D. Molkentin, E.M. McNally. Targeting latent TGFβ release in muscular dystrophy.Sci Transl Med. 2014 Oct 22;6(259):259ra144. PMID: 25338755

Moorwood, C., and E.R. Barton. (2014) Caspase-12 ablation rescues muscle function in the mdx mouse. Hum Mol Gen, 23(20): 5325-41. PMCID: PMC4168821

Moorwood, C., M. Liu, Z. Tian, and E.R. Barton (2013). Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies.JoVE. (71). doi:pii: 50036. 10.3791/50036. PMID: 23407283

Morine K., M.M. Sleeper, E.R. Barton, H.L. Sweeney. (2010) Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction induced damage. Hum Gene Ther. 21(12):1735-9 PMCID: PMC2954636

Zou, Y., D. Zwolanek, Y. Izu, S. Gandhy, G. Schreiber, K. Brockmann, M. Devoto, Z. Tian, Y. Hu, G. Veit, M. Meier, J. Stetefeld, D. Hicks, V. Straub, N.C. Voermans, D.E. Birk, E.R. Barton, M. Koch, C.G. Bonnemann. (2014) Recessive and dominant mutations in COL12A1 cause a novel EDS/myopathy overlap syndrome in human and mice. Hum Mol Gen, 23(9):2339-52. PMCID: PMC3976332