In Situ Mechanical Stimulation

In Situ Mechanical Stimulation graphs

Figure 4. In situ TA muscle mechanics. A) Protocol for assessing contractile damage in TA muscles in situ. (B) Dystrophic gsg-/- and mdx tibialis anterior (TA) muscles generate less force than C57 muscles when subjected to in situ isometric mechanical stimulation. (C) Mice with primary g-SG deficiency do not show compromised force generating capacity following in situ eccentric contraction mechanical injury, whereas mdx mice show a significant increase in force drop. * , P < 0.001 vs. C57; † , P < 0.01 vs. gsg-/- by one-way ANOVA with Bonferroni post-hoc test, n = 5-7.

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